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Differentiation: IGF-1 is often described as a maturation factor because it can influence both proliferation and the differentiation of progenitor cells into specialized cell types

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This attachment initiates a cascade of intracellular signaling events, with insulin receptor substrate - 1 (IRS - 1) serving as a critical intermediary (Walte et al., 2024)

Safety and efficacy of plerixafor dose escalation for the mobilization of CD34(+) hematopoietic progenitor cells in patients with sickle cell disease: interim results